:root {
  --navy: #171c60;
  --navy-deep: #0b103d;
  --coral: #ef6068;
  --coral-dark: #d84750;
  --moss: #52755f;
  --moss-dark: #294c3b;
  --sage: #dfe9e1;
  --sage-pale: #f1f5f0;
  --cream: #f7f4ed;
  --paper: #fffefb;
  --ink: #1d2235;
  --slate: #606777;
  --line: #dde1e8;
  --white: #fff;
  --shadow: 0 24px 70px rgba(15,20,63,.12);
  --shadow-soft: 0 12px 34px rgba(15,20,63,.08);
  --wrap: 1180px;
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; overflow-x: clip; }
body {
  margin: 0;
  color: var(--ink);
  background: var(--paper);
  font-family: Inter, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  line-height: 1.6;
  -webkit-font-smoothing: antialiased;
}
body.menu-open { overflow: hidden; }
img { display: block; max-width: 100%; }
a { color: inherit; text-decoration: none; }
button, a { -webkit-tap-highlight-color: transparent; }
h1, h2, h3, p, figure, blockquote { margin-top: 0; }
h1, h2, h3 {
  color: var(--navy);
  letter-spacing: -.035em;
  line-height: 1.08;
}
h1, h2 { font-family: "Playfair Display", Georgia, serif; font-weight: 500; }
h1 em, h2 em { color: var(--coral-dark); font-weight: 500; }
.wrap { width: min(calc(100% - 48px), var(--wrap)); margin-inline: auto; }
.section { padding: 110px 0; }
.section.cream { background: var(--cream); }
.section.sage { background: var(--sage-pale); }
.section.navy { color: var(--white); background: var(--navy-deep); }
.section.moss { color: var(--white); background: var(--moss-dark); }
.section.navy h2, .section.navy h3, .section.moss h2, .section.moss h3 { color: var(--white); }
.section.navy .lead, .section.moss .lead { color: rgba(255,255,255,.68); }
.eyebrow {
  display: flex;
  align-items: center;
  gap: 10px;
  margin-bottom: 18px;
  color: var(--coral-dark);
  font: 600 12px/1.2 "DM Mono", monospace;
  letter-spacing: .12em;
  text-transform: uppercase;
}
.eyebrow::before {
  width: 28px;
  height: 2px;
  background: currentColor;
  content: "";
}
.navy .eyebrow, .hero-dark .eyebrow { color: #ff9ca2; }
.moss .eyebrow, .hero-moss .eyebrow { color: #c8dfcd; }
.display {
  max-width: 920px;
  margin-bottom: 24px;
  font-size: clamp(40px, 5.2vw, 68px);
}
.lead {
  max-width: 780px;
  color: var(--slate);
  font-size: clamp(18px, 2vw, 22px);
  line-height: 1.65;
}
.fine-print { color: var(--slate); font-size: 12px; }
.btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 52px;
  padding: 0 24px;
  border: 1px solid transparent;
  border-radius: 999px;
  font-weight: 700;
  transition: transform .2s ease, background .2s ease, border-color .2s ease;
}
.btn:hover { transform: translateY(-2px); }
.btn-primary { color: var(--white); background: var(--coral); }
.btn-primary:hover { background: var(--coral-dark); }
.btn-outline { border-color: rgba(23,28,96,.25); color: var(--navy); }
.btn-outline:hover { border-color: var(--navy); background: rgba(23,28,96,.04); }
.btn-light { color: var(--navy); background: var(--white); }
.btn-outline-light { border-color: rgba(255,255,255,.38); color: var(--white); }
.btn-outline-light:hover { border-color: var(--white); background: rgba(255,255,255,.08); }
.text-link {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  color: var(--navy);
  font-weight: 700;
}
.text-link::after { color: var(--coral); content: "↗"; }
.navy .text-link, .moss .text-link { color: var(--white); }
.reveal {
  opacity: 0;
  transform: translateY(20px);
  transition: opacity .7s ease, transform .7s ease;
}
.reveal.is-visible { opacity: 1; transform: none; }

/* Navigation */
.site-header { position: relative; z-index: 40; color: var(--white); background: var(--navy-deep); }
.nav { display: flex; align-items: center; justify-content: space-between; height: 88px; }
.logo-panel {
  display: inline-flex;
  align-items: center;
  padding: 7px 11px;
  border-radius: 12px;
  background: rgba(255,255,255,.97);
  box-shadow: 0 8px 28px rgba(0,0,0,.13);
}
.logo { width: 214px; }
.nav-links { display: flex; align-items: center; gap: 22px; }
.nav-links a { color: rgba(255,255,255,.76); font-size: 13px; font-weight: 600; }
.nav-links a:hover, .nav-links a.current { color: var(--white); }
.nav-links a.current { box-shadow: inset 0 -2px #ff9ca2; }
.nav-links .nav-product {
  padding: 10px 15px;
  border: 1px solid rgba(255,255,255,.38);
  border-radius: 999px;
  color: var(--white);
  box-shadow: none;
}
.menu-toggle {
  display: none;
  width: 44px;
  height: 44px;
  padding: 0;
  border: 1px solid rgba(255,255,255,.35);
  border-radius: 50%;
  color: var(--white);
  background: transparent;
  font-size: 20px;
}

/* Heroes */
.cp-hero { position: relative; overflow: hidden; }
.hero-dark {
  color: var(--white);
  background:
    radial-gradient(circle at 86% 14%, rgba(239,96,104,.23), transparent 29%),
    radial-gradient(circle at 9% 92%, rgba(82,117,95,.27), transparent 29%),
    linear-gradient(138deg, var(--navy) 0%, var(--navy-deep) 76%);
}
.hero-light {
  background:
    radial-gradient(circle at 88% 18%, rgba(223,233,225,.9), transparent 29%),
    linear-gradient(118deg, var(--cream) 0 66%, #edf3ed 66% 100%);
}
.hero-moss {
  color: var(--white);
  background:
    radial-gradient(circle at 86% 18%, rgba(255,255,255,.13), transparent 29%),
    linear-gradient(135deg, #3f6651 0%, var(--moss-dark) 76%);
}
.cp-hero::before {
  position: absolute;
  inset: 0;
  opacity: .35;
  background-image:
    linear-gradient(rgba(255,255,255,.045) 1px, transparent 1px),
    linear-gradient(90deg, rgba(255,255,255,.045) 1px, transparent 1px);
  background-size: 58px 58px;
  mask-image: linear-gradient(90deg, #000, transparent 78%);
  content: "";
}
.hero-light::before {
  opacity: .6;
  background-image:
    linear-gradient(rgba(23,28,96,.04) 1px, transparent 1px),
    linear-gradient(90deg, rgba(23,28,96,.04) 1px, transparent 1px);
}
.hero-grid {
  display: grid;
  position: relative;
  grid-template-columns: 1.05fr .95fr;
  gap: 70px;
  align-items: center;
  min-height: 700px;
  padding: 78px 0 90px;
}
.hero-copy h1 {
  max-width: 790px;
  margin-bottom: 27px;
  font-size: clamp(49px, 6vw, 80px);
}
.hero-dark .hero-copy h1, .hero-moss .hero-copy h1 { color: var(--white); }
.hero-dark .hero-copy h1 em { color: #ff9ca2; }
.hero-moss .hero-copy h1 em { color: #dceadf; }
.hero-dark .hero-copy .lead, .hero-moss .hero-copy .lead { color: rgba(255,255,255,.74); }
.hero-dark .hero-copy .lead strong { color: var(--white); }
.hero-definition {
  max-width: 690px;
  margin-top: 25px;
  padding: 17px 19px;
  border-left: 3px solid var(--coral);
  background: rgba(255,255,255,.075);
}
.hero-definition span {
  display: block;
  margin-bottom: 7px;
  color: #ffabb1;
  font: 600 9px/1.2 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.hero-definition p { margin: 0; color: rgba(255,255,255,.8); font-size: 14px; line-height: 1.55; }
.hero-actions { display: flex; flex-wrap: wrap; gap: 12px; margin-top: 34px; }
.hero-note { max-width: 670px; margin: 24px 0 0; color: var(--slate); font-size: 12px; }
.hero-dark .hero-note, .hero-moss .hero-note { color: rgba(255,255,255,.54); }
.visual-card {
  position: relative;
  min-height: 490px;
  padding: 31px;
  overflow: hidden;
  border: 1px solid rgba(255,255,255,.16);
  border-radius: 28px;
  background: rgba(255,255,255,.075);
  box-shadow: 0 28px 70px rgba(0,0,0,.2);
  backdrop-filter: blur(10px);
}
.hero-light .visual-card {
  border-color: rgba(23,28,96,.1);
  background: rgba(255,255,255,.74);
  box-shadow: var(--shadow);
}
.visual-top {
  display: flex;
  position: relative;
  z-index: 2;
  justify-content: space-between;
  padding-bottom: 18px;
  border-bottom: 1px solid rgba(255,255,255,.15);
  color: rgba(255,255,255,.58);
  font: 500 10px/1.3 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.hero-light .visual-top { border-color: var(--line); color: var(--slate); }
.visual-list { position: relative; z-index: 2; margin-top: 24px; }
.visual-row {
  display: grid;
  grid-template-columns: 70px 1fr;
  gap: 20px;
  padding: 20px 0;
  border-bottom: 1px solid rgba(255,255,255,.13);
}
.hero-light .visual-row { border-color: var(--line); }
.visual-row:last-child { border-bottom: 0; }
.visual-row > span {
  color: #ffabb1;
  font: 500 26px/1 "Playfair Display", Georgia, serif;
}
.hero-light .visual-row > span { color: var(--coral-dark); }
.visual-row strong { display: block; margin-bottom: 5px; color: var(--white); }
.hero-light .visual-row strong { color: var(--navy); }
.visual-row p { margin-bottom: 0; color: rgba(255,255,255,.63); font-size: 12px; }
.hero-light .visual-row p { color: var(--slate); }
.visual-quote {
  position: relative;
  z-index: 2;
  margin: 42px 0 0;
  color: var(--white);
  font: 500 28px/1.3 "Playfair Display", Georgia, serif;
}
.hero-light .visual-quote { color: var(--navy); }
.visual-caption { position: relative; z-index: 2; margin-top: 15px; color: rgba(255,255,255,.58); font-size: 11px; }
.hero-light .visual-caption { color: var(--slate); }
.mirna-hero-card {
  position: relative;
  width: 100%;
  aspect-ratio: 1;
  margin: 0;
  overflow: hidden;
  border: 1px solid rgba(255,255,255,.17);
  border-radius: 28px;
  color: var(--white);
  background: rgba(255,255,255,.07);
  box-shadow: 0 28px 70px rgba(0,0,0,.22);
}
.mirna-hero-card::after {
  position: absolute;
  inset: 0;
  z-index: 1;
  background: linear-gradient(180deg, rgba(8,11,46,.02) 0%, rgba(8,11,46,.08) 42%, rgba(8,11,46,.94) 72%, rgba(8,11,46,.99) 100%);
  content: "";
}
.mirna-hero-card > img {
  position: absolute;
  inset: 0;
  width: 100%;
  height: 100%;
  object-fit: cover;
  object-position: center;
}
.mirna-hero-card figcaption {
  position: absolute;
  z-index: 2;
  right: 0;
  bottom: 0;
  left: 0;
  padding: 32px;
}
.mirna-visual-label {
  margin-bottom: 8px;
  color: #ffabb1;
  font: 600 9px/1.2 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.mirna-hero-card h2 { max-width: 500px; margin-bottom: 9px; color: var(--white); font-size: clamp(25px, 3vw, 34px); }
.mirna-hero-card figcaption > p { max-width: 500px; margin-bottom: 7px; color: rgba(255,255,255,.76); font-size: 11px; }
.mirna-hero-card figcaption > p strong { color: var(--white); }
.mirna-hero-card figcaption > small { color: rgba(255,255,255,.5); font-size: 9px; }
.mirna-pathway-card { display: grid; aspect-ratio: auto; grid-template-rows: auto auto; }
.mirna-pathway-card::after { display: none; }
.mirna-pathway-card > img {
  position: static;
  width: 100%;
  height: auto;
  aspect-ratio: 1;
  object-fit: cover;
}
.mirna-pathway-card figcaption {
  position: static;
  padding: 27px 30px 29px;
  border-top: 1px solid rgba(255,255,255,.12);
  background: linear-gradient(145deg, rgba(255,255,255,.075), rgba(255,255,255,.025));
}
.mirna-visual-flow { display: grid; gap: 7px; }
.mirna-visual-flow > div {
  display: grid;
  grid-template-columns: 27px 1fr;
  gap: 11px;
  align-items: center;
  padding: 9px 11px;
  border: 1px solid rgba(255,255,255,.12);
  border-radius: 11px;
  background: rgba(255,255,255,.055);
}
.mirna-visual-flow span {
  display: grid;
  width: 27px;
  height: 27px;
  place-content: center;
  border-radius: 50%;
  color: var(--navy-deep);
  background: #ffabb1;
  font: 700 10px/1 Inter, sans-serif;
}
.mirna-visual-flow > div:nth-child(2) span,
.mirna-visual-flow > div:nth-child(4) span { background: #b9d7c0; }
.mirna-visual-flow strong { color: rgba(255,255,255,.9); font-size: 11px; line-height: 1.35; }

/* Shared sections */
.section-intro {
  display: grid;
  grid-template-columns: 1fr .72fr;
  gap: 70px;
  align-items: end;
  margin-bottom: 58px;
}
.section-intro .display { margin-bottom: 0; }
.summary-strip { border-bottom: 1px solid var(--line); background: var(--white); }
.summary-grid { display: grid; grid-template-columns: repeat(4, 1fr); }
.summary-grid.summary-grid-three { grid-template-columns: repeat(3, 1fr); }
.summary-grid.summary-grid-two { grid-template-columns: repeat(2, 1fr); }
.summary-item { padding: 25px; border-right: 1px solid var(--line); }
.summary-item:first-child { padding-left: 0; }
.summary-item:last-child { padding-right: 0; border-right: 0; }
.summary-item span {
  display: block;
  margin-bottom: 7px;
  color: var(--coral-dark);
  font: 600 10px/1.3 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.summary-item strong { display: block; color: var(--navy); font-size: 14px; line-height: 1.45; }
.card-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 22px; }
.card-grid.two { grid-template-columns: 1fr 1fr; }
.card-grid.four { grid-template-columns: repeat(4, 1fr); }
.info-card {
  display: flex;
  min-height: 330px;
  padding: 32px;
  border: 1px solid var(--line);
  border-radius: 23px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
  flex-direction: column;
}
.info-card.dark {
  border-color: rgba(255,255,255,.14);
  background: rgba(255,255,255,.06);
  box-shadow: none;
}
.route-card {
  position: relative;
  min-height: 360px;
  overflow: hidden;
  border: 1px solid rgba(23,28,96,.14);
  box-shadow: 0 22px 55px rgba(0,0,0,.2);
}
.route-card::before {
  position: absolute;
  top: 0;
  right: 0;
  left: 0;
  height: 7px;
  background: var(--moss);
  content: "";
}
.route-card.route-mironcol { background: linear-gradient(145deg, var(--white), var(--sage-pale)); }
.route-card.route-micheckup { background: linear-gradient(145deg, var(--white), #fff1f0); }
.route-card.route-micheckup::before { background: var(--coral); }
.route-brand {
  display: flex;
  align-items: center;
  min-height: 52px;
  margin: 8px 0 23px;
}
.route-brand img { width: auto; max-width: min(250px, 80%); max-height: 52px; object-fit: contain; }
.route-card .card-code {
  align-self: flex-start;
  margin-bottom: 31px;
  padding: 9px 12px;
  border-radius: 999px;
  color: var(--white);
  background: var(--moss-dark);
  font-size: 10px;
}
.route-card.route-micheckup .card-code { color: var(--white); background: var(--coral-dark); }
.section.navy .route-card h3 { color: var(--navy); font-size: 27px; }
.section.navy .route-card p { color: var(--slate); }
.section.navy .route-card .text-link { color: var(--navy); }
.card-code {
  display: block;
  margin-bottom: 65px;
  color: var(--coral-dark);
  font: 600 11px/1.2 "DM Mono", monospace;
  letter-spacing: .1em;
}
.dark .card-code { color: #ffabb1; }
.info-card h3 { margin-bottom: 13px; font: 650 23px/1.16 Inter, sans-serif; }
.info-card p { margin-bottom: 0; color: var(--slate); font-size: 14px; }
.info-card.dark p { color: rgba(255,255,255,.65); }
.info-card .text-link { margin-top: auto; padding-top: 22px; font-size: 13px; }
.callout {
  display: grid;
  grid-template-columns: .72fr 1.28fr;
  gap: 60px;
  align-items: center;
  padding: 48px;
  border: 1px solid var(--line);
  border-radius: 26px;
  background: var(--white);
  box-shadow: var(--shadow);
}
.callout h3 { margin-bottom: 14px; font: 650 28px/1.15 Inter, sans-serif; }
.callout p { margin-bottom: 0; color: var(--slate); }
.callout-stat {
  color: var(--navy);
  font: 500 clamp(60px, 8vw, 100px)/.9 "Playfair Display", Georgia, serif;
  letter-spacing: -.06em;
}
.callout-stat.callout-stat-words {
  max-width: 470px;
  font-size: clamp(42px, 5vw, 68px);
  line-height: .98;
  letter-spacing: -.045em;
}
.callout-label { display: block; margin-top: 13px; color: var(--coral-dark); font: 600 10px/1.4 "DM Mono", monospace; letter-spacing: .1em; text-transform: uppercase; }

/* microRNA page */
.control-stack { display: grid; gap: 13px; margin-top: 35px; }
.control-layer {
  display: grid;
  grid-template-columns: 105px 1fr;
  gap: 20px;
  align-items: center;
  padding: 21px 23px;
  border: 1px solid rgba(255,255,255,.14);
  border-radius: 16px;
  background: rgba(255,255,255,.055);
}
.hero-light .control-layer { border-color: var(--line); background: rgba(255,255,255,.75); }
.control-layer span { color: #ffabb1; font: 600 10px/1.3 "DM Mono", monospace; letter-spacing: .08em; }
.hero-light .control-layer span { color: var(--coral-dark); }
.control-layer strong { color: var(--white); font-size: 15px; }
.hero-light .control-layer strong { color: var(--navy); }
.control-arrow { height: 22px; margin-left: 50px; border-left: 1px solid rgba(255,255,255,.3); }
.hero-light .control-arrow { border-color: rgba(23,28,96,.2); }
.video-feature {
  display: grid;
  grid-template-columns: 1.2fr .8fr;
  overflow: hidden;
  border: 1px solid rgba(255,255,255,.14);
  border-radius: 26px;
  background: rgba(255,255,255,.06);
}
.video-frame { position: relative; min-height: 430px; background: #050727; }
.video-frame iframe { position: absolute; inset: 0; width: 100%; height: 100%; border: 0; }
.video-copy { display: flex; padding: 39px; flex-direction: column; justify-content: center; }
.video-copy h3 { margin-bottom: 18px; font: 500 34px/1.16 "Playfair Display", Georgia, serif; }
.video-copy p { color: rgba(255,255,255,.68); font-size: 14px; }
.video-copy small { color: rgba(255,255,255,.47); font-size: 11px; }
.pathway {
  display: grid;
  grid-template-columns: repeat(5, 1fr);
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 24px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
}
.pathway-step { position: relative; min-height: 260px; padding: 29px 24px; border-right: 1px solid var(--line); }
.pathway-step:last-child { border-right: 0; }
.pathway-step:not(:last-child)::after {
  position: absolute;
  top: 36px;
  right: -8px;
  z-index: 2;
  color: var(--coral);
  content: "→";
}
.pathway-step span { display: block; margin-bottom: 75px; color: var(--coral-dark); font: 600 10px/1.2 "DM Mono", monospace; letter-spacing: .1em; }
.pathway-step h3 { margin-bottom: 11px; font: 650 18px/1.2 Inter, sans-serif; }
.pathway-step p { margin-bottom: 0; color: var(--slate); font-size: 12px; }

/* Longitudinal page */
.mode-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 24px; }
.mode-card {
  min-height: 360px;
  padding: 37px;
  border: 1px solid var(--line);
  border-radius: 24px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
}
.mode-card.longitudinal { color: var(--white); border-color: var(--moss-dark); background: var(--moss-dark); }
.mode-label { display: block; margin-bottom: 75px; color: var(--coral-dark); font: 600 10px/1.3 "DM Mono", monospace; letter-spacing: .1em; text-transform: uppercase; }
.longitudinal .mode-label { color: #c8dfcd; }
.mode-card h3 { margin-bottom: 15px; font: 650 27px/1.15 Inter, sans-serif; }
.mode-card.longitudinal h3 { color: var(--white); }
.mode-card p { color: var(--slate); }
.mode-card.longitudinal p { color: rgba(255,255,255,.68); }
.trajectory-shell {
  padding: 30px;
  border: 1px solid var(--line);
  border-radius: 25px;
  background: var(--white);
  box-shadow: var(--shadow);
}
.trajectory-head { display: flex; justify-content: space-between; gap: 30px; margin-bottom: 18px; }
.trajectory-head h3 { margin-bottom: 7px; font: 650 22px/1.2 Inter, sans-serif; }
.trajectory-head p { margin-bottom: 0; color: var(--slate); font-size: 12px; }
.trajectory-tag { color: var(--coral-dark); font: 600 10px/1.4 "DM Mono", monospace; letter-spacing: .08em; text-transform: uppercase; }
.trajectory-canvas { display: block; width: 100%; height: 380px; }
.timeline-notes { display: grid; grid-template-columns: repeat(5, 1fr); gap: 12px; margin-top: 20px; }
.timeline-note { padding: 17px; border-radius: 14px; background: var(--sage-pale); }
.timeline-note span { display: block; margin-bottom: 8px; color: var(--coral-dark); font: 600 9px/1.3 "DM Mono", monospace; letter-spacing: .08em; }
.timeline-note strong { display: block; margin-bottom: 6px; color: var(--navy); font-size: 13px; }
.timeline-note p { margin-bottom: 0; color: var(--slate); font-size: 10px; line-height: 1.5; }
.quote-feature {
  display: grid;
  grid-template-columns: 170px 1fr;
  gap: 34px;
  align-items: center;
  padding: 38px;
  border-radius: 24px;
  color: var(--white);
  background: var(--navy);
}
.quote-photo { width: 150px; aspect-ratio: 1; object-fit: cover; object-position: center 18%; border: 5px solid rgba(255,255,255,.16); border-radius: 50%; }
.quote-feature blockquote { margin-bottom: 17px; color: var(--white); font: 500 clamp(27px, 4vw, 43px)/1.25 "Playfair Display", Georgia, serif; letter-spacing: -.035em; }
.quote-credit { color: rgba(255,255,255,.62); font-size: 12px; }
.quote-credit strong { color: var(--white); }

/* Profiles and partners */
.story-image-grid {
  display: grid;
  grid-template-columns: 1.15fr .925fr .925fr;
  gap: 16px;
  margin: 0 0 28px;
}
.story-image-card {
  position: relative;
  min-height: 285px;
  margin: 0;
  overflow: hidden;
  border-radius: 22px;
  background: var(--navy);
  box-shadow: var(--shadow-soft);
  isolation: isolate;
}
.story-image-card::after {
  position: absolute;
  inset: 0;
  z-index: -1;
  background: linear-gradient(0deg, rgba(8,21,51,.9) 0%, rgba(8,21,51,.08) 67%, transparent 100%);
  content: "";
}
.story-image-card img {
  position: absolute;
  inset: 0;
  z-index: -2;
  width: 100%;
  height: 100%;
  object-fit: cover;
}
.story-image-card figcaption {
  position: absolute;
  right: 0;
  bottom: 0;
  left: 0;
  padding: 24px;
}
.story-image-card span {
  display: block;
  margin-bottom: 7px;
  color: #ffabb1;
  font: 600 9px/1.3 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.story-image-card strong {
  display: block;
  color: var(--white);
  font: 500 clamp(20px, 2.2vw, 29px)/1.18 "Playfair Display", Georgia, serif;
}
.profile-grid, .partner-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 22px; }
.profile-card, .partner-card {
  display: flex;
  min-height: 365px;
  padding: 31px;
  border: 1px solid var(--line);
  border-radius: 23px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
  flex-direction: column;
}
.profile-card:nth-child(2n), .partner-card:nth-child(2n) { background: var(--sage-pale); }
.profile-tag, .partner-tag { display: block; margin-bottom: 65px; color: var(--coral-dark); font: 600 10px/1.3 "DM Mono", monospace; letter-spacing: .1em; text-transform: uppercase; }
.profile-card h3, .partner-card h3 { margin-bottom: 13px; font: 650 22px/1.18 Inter, sans-serif; }
.profile-card p, .partner-card p { margin-bottom: 0; color: var(--slate); font-size: 14px; }
.profile-card .text-link, .partner-card .text-link { margin-top: auto; padding-top: 22px; font-size: 13px; }
.fit-panel {
  display: grid;
  grid-template-columns: 1fr 1fr;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 25px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
}
.fit-side { padding: 39px; }
.fit-side:first-child { border-right: 1px solid var(--line); background: var(--sage-pale); }
.fit-side span { display: block; margin-bottom: 35px; color: var(--coral-dark); font: 600 10px/1.3 "DM Mono", monospace; letter-spacing: .1em; text-transform: uppercase; }
.fit-side h3 { margin-bottom: 15px; font: 650 25px/1.16 Inter, sans-serif; }
.fit-side ul { margin: 0; padding-left: 18px; color: var(--slate); }
.fit-side li { margin-bottom: 10px; }
.partner-flow { display: grid; grid-template-columns: repeat(4, 1fr); overflow: hidden; border: 1px solid rgba(255,255,255,.15); border-radius: 24px; }
.partner-step { position: relative; min-height: 300px; padding: 29px; border-right: 1px solid rgba(255,255,255,.14); }
.partner-step:last-child { border-right: 0; }
.partner-step span { display: block; margin-bottom: 80px; color: #ffabb1; font: 600 11px/1.3 "DM Mono", monospace; letter-spacing: .1em; }
.partner-step h3 { margin-bottom: 12px; font: 650 21px/1.18 Inter, sans-serif; }
.partner-step p { color: rgba(255,255,255,.66); font-size: 13px; }

/* Audience and partner detail pages */
.detail-photo-break { padding: 44px 0 6px; background: var(--white); }
.detail-photo-feature {
  position: relative;
  display: grid;
  min-height: 390px;
  margin: 0;
  overflow: hidden;
  border-radius: 28px;
  background: var(--navy);
  box-shadow: var(--shadow);
  isolation: isolate;
}
.detail-photo-feature::after {
  position: absolute;
  inset: 0;
  z-index: -1;
  content: "";
  background: linear-gradient(90deg, rgba(8,21,51,.9) 0%, rgba(8,21,51,.58) 38%, rgba(8,21,51,.04) 76%);
}
.detail-photo-feature img {
  position: absolute;
  inset: 0;
  z-index: -2;
  width: 100%;
  height: 100%;
  object-fit: cover;
}
.detail-photo-feature figcaption {
  align-self: end;
  max-width: 620px;
  padding: 38px 42px;
  color: var(--white);
}
.detail-photo-feature figcaption span {
  display: block;
  margin-bottom: 12px;
  color: #ffabb1;
  font: 600 10px/1.3 "DM Mono", monospace;
  letter-spacing: .11em;
  text-transform: uppercase;
}
.detail-photo-feature figcaption strong {
  display: block;
  color: var(--white);
  font: 500 clamp(26px, 3.4vw, 43px)/1.12 "Playfair Display", Georgia, serif;
  letter-spacing: -.025em;
}
.evidence-image-card {
  display: grid;
  grid-template-columns: minmax(0, 1.45fr) minmax(280px, .55fr);
  gap: 0;
  align-items: stretch;
  margin: 34px 0 0;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 24px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
}
.evidence-image-card img { width: 100%; height: 100%; min-height: 310px; object-fit: cover; }
.evidence-image-card figcaption { align-self: center; padding: 34px; }
.evidence-image-card figcaption span { display: block; margin-bottom: 18px; color: var(--coral-dark); font: 600 10px/1.3 "DM Mono", monospace; letter-spacing: .1em; text-transform: uppercase; }
.evidence-image-card figcaption strong { display: block; margin-bottom: 14px; color: var(--navy); font: 500 27px/1.18 "Playfair Display", Georgia, serif; }
.evidence-image-card figcaption p { margin: 0; color: var(--slate); font-size: 13px; }
.mirna-pattern-layout {
  display: grid;
  grid-template-columns: minmax(0, 1fr) minmax(420px, .82fr);
  gap: 62px;
  align-items: start;
}
.pattern-explanation { display: grid; gap: 0; }
.pattern-explanation > article {
  display: grid;
  grid-template-columns: 145px 1fr;
  column-gap: 24px;
  padding: 24px 0;
  border-top: 1px solid var(--line);
}
.pattern-explanation > article > span {
  grid-row: 1 / 3;
  color: var(--coral-dark);
  font: 600 10px/1.4 "DM Mono", monospace;
  letter-spacing: .09em;
}
.pattern-explanation h3 { margin-bottom: 8px; font: 650 22px/1.18 Inter, sans-serif; }
.pattern-explanation p { margin: 0; color: var(--slate); font-size: 14px; }
.pattern-proof {
  margin-top: 18px;
  padding: 25px 27px;
  border-left: 4px solid var(--coral);
  border-radius: 0 18px 18px 0;
  background: var(--white);
  box-shadow: var(--shadow-soft);
}
.pattern-proof > span {
  display: block;
  margin-bottom: 9px;
  color: var(--coral-dark);
  font: 600 10px/1.3 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.pattern-proof p { margin-bottom: 11px; color: var(--ink); font-size: 14px; }
.pattern-proof .text-link { font-size: 13px; }
.pattern-proof-card {
  display: grid;
  aspect-ratio: 1;
  margin: 0;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 24px;
  background: var(--white);
  box-shadow: var(--shadow);
  grid-template-rows: minmax(0, 1fr) auto;
}
.pattern-proof-image {
  display: grid;
  min-height: 0;
  padding: 22px 18px 8px;
  place-items: center;
  overflow: hidden;
  background: #fff;
}
.pattern-proof-image img { width: 100%; height: 100%; object-fit: contain; }
.pattern-proof-card figcaption { padding: 22px 25px 24px; border-top: 1px solid var(--line); }
.pattern-proof-card figcaption span { display: block; margin-bottom: 8px; color: var(--coral-dark); font: 600 9px/1.3 "DM Mono", monospace; letter-spacing: .1em; text-transform: uppercase; }
.pattern-proof-card figcaption strong { display: block; margin-bottom: 7px; color: var(--navy); font-size: 16px; line-height: 1.3; }
.pattern-proof-card figcaption p { margin: 0; color: var(--slate); font-size: 11px; line-height: 1.5; }

/* Why microRNA: credibility, explanation and longitudinal value */
.comparison-banner { color: var(--white); background: var(--coral-dark); }
.comparison-banner-inner {
  display: flex;
  min-height: 48px;
  align-items: center;
  justify-content: space-between;
  gap: 20px;
  font: 500 11px/1.4 "DM Mono", monospace;
  letter-spacing: .04em;
}
.comparison-banner-inner a { padding-bottom: 2px; border-bottom: 1px solid rgba(255,255,255,.72); font-weight: 700; }
.combined-foundation { background: var(--cream); }
.combined-foundation-grid {
  display: grid;
  grid-template-columns: 1.08fr .92fr;
  min-height: 610px;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 28px;
  background: var(--white);
  box-shadow: var(--shadow);
}
.combined-video { position: relative; min-height: 520px; background: var(--navy-deep); }
.combined-video iframe { position: absolute; inset: 0; width: 100%; height: 100%; border: 0; }
.combined-foundation-copy { display: flex; padding: 48px; justify-content: center; flex-direction: column; }
.combined-foundation-copy h2 { margin-bottom: 23px; font-size: clamp(42px, 4.8vw, 64px); }
.combined-foundation-copy .lead { margin-bottom: 17px; color: var(--ink); font-size: 18px; line-height: 1.6; }
.combined-foundation-copy > p:not(.lead) { margin-bottom: 24px; color: var(--slate); font-size: 14px; }
.combined-nobel-mark {
  display: grid;
  grid-template-columns: 90px 1fr;
  gap: 20px;
  align-items: center;
  margin: 3px 0 19px;
  padding: 20px;
  border-left: 3px solid var(--coral);
  background: var(--sage-pale);
}
.combined-nobel-mark strong { color: var(--navy); font: 500 43px/1 "Playfair Display", Georgia, serif; }
.combined-nobel-mark span { color: var(--ink); font-size: 12px; line-height: 1.5; }
.combined-foundation-copy > small { color: var(--slate); font-size: 10px; }
.consolidated-proof-section {
  background:
    radial-gradient(circle at 92% 4%, rgba(223,233,225,.72), transparent 31%),
    var(--paper);
}
.published-proof-wide {
  display: grid;
  grid-template-columns: .72fr 1.28fr;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 27px;
  background: var(--white);
  box-shadow: var(--shadow);
}
.published-proof-identity {
  display: flex;
  min-height: 430px;
  padding: 38px;
  border-right: 1px solid var(--line);
  background:
    radial-gradient(circle at 0 100%, rgba(239,96,104,.11), transparent 45%),
    var(--sage-pale);
  flex-direction: column;
}
.published-proof-identity > span {
  color: var(--coral-dark);
  font: 600 10px/1.3 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.published-proof-identity > strong {
  margin: 15px 0 auto;
  color: rgba(23,28,96,.12);
  font: 700 clamp(70px, 8vw, 112px)/.82 Inter, sans-serif;
  letter-spacing: -.075em;
}
.published-proof-identity .published-logo-wrap { margin-bottom: 0; }
.published-proof-copy { display: flex; padding: 48px; justify-content: center; flex-direction: column; }
.published-proof-copy h2 { max-width: 690px; margin-bottom: 20px; font-size: clamp(36px, 4vw, 55px); }
.published-proof-copy p { max-width: 660px; margin-bottom: 30px; color: var(--slate); font-size: 15px; }
.published-proof-copy .text-link { font-size: 13px; }
.proof-section {
  background:
    radial-gradient(circle at 92% 4%, rgba(223,233,225,.72), transparent 30%),
    var(--paper);
}
.proof-heading { max-width: 970px; margin-bottom: 52px; }
.proof-heading .display { max-width: 970px; margin-bottom: 20px; }
.credibility-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 24px;
}
.credibility-card {
  display: flex;
  min-height: 540px;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 27px;
  box-shadow: var(--shadow);
  flex-direction: column;
}
.credibility-card-nobel {
  color: var(--white);
  border-color: rgba(255,255,255,.12);
  background:
    radial-gradient(circle at 100% 0, rgba(239,96,104,.23), transparent 39%),
    linear-gradient(145deg, var(--navy) 0%, var(--navy-deep) 82%);
}
.credibility-card-published {
  background:
    radial-gradient(circle at 100% 0, rgba(223,233,225,.88), transparent 44%),
    var(--white);
}
.credibility-topline {
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 22px 28px;
  border-bottom: 1px solid var(--line);
  color: var(--coral-dark);
  font: 600 10px/1.3 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.credibility-card-nobel .credibility-topline {
  border-color: rgba(255,255,255,.14);
  color: #ffabb1;
}
.credibility-topline strong { font-size: 17px; letter-spacing: .08em; }
.credibility-body { display: flex; flex: 1; padding: 38px; flex-direction: column; }
.credibility-mark {
  margin: 4px 0 42px;
  color: rgba(255,255,255,.13);
  font: 700 clamp(68px, 8vw, 112px)/.78 Inter, sans-serif;
  letter-spacing: -.075em;
}
.credibility-card h3 {
  max-width: 600px;
  margin-bottom: 17px;
  font: 500 clamp(28px, 3vw, 39px)/1.12 "Playfair Display", Georgia, serif;
  letter-spacing: -.025em;
}
.credibility-card-nobel h3 { color: var(--white); }
.credibility-card p { margin-bottom: 22px; color: var(--slate); font-size: 14px; }
.credibility-card-nobel p { color: rgba(255,255,255,.66); }
.credibility-card .text-link { margin-top: auto; font-size: 13px; }
.credibility-card-nobel .text-link { color: var(--white); }
.published-logo-wrap {
  display: flex;
  min-height: 92px;
  align-items: center;
  gap: 18px;
  margin: 0 0 29px;
}
.published-logo-wrap img { width: min(230px, 56%); }
.published-logo-wrap span {
  max-width: 150px;
  color: var(--slate);
  font: 600 10px/1.45 "DM Mono", monospace;
  letter-spacing: .07em;
  text-transform: uppercase;
}
.micro-process { display: grid; grid-template-columns: repeat(4, 1fr); gap: 18px; }
.micro-process-step {
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 22px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
}
.micro-process-step figure { height: 190px; margin: 0; overflow: hidden; background: var(--navy-deep); }
.micro-process-step figure img { width: 100%; height: 100%; object-fit: cover; }
.micro-process-step:first-child figure img { object-position: 52% center; }
.micro-process-copy { padding: 25px 23px 28px; }
.micro-process-copy > span,
.longitudinal-story article > span,
.future-value-callout span,
.disease-direction-copy > span {
  display: block;
  margin-bottom: 20px;
  color: var(--coral-dark);
  font: 600 10px/1.35 "DM Mono", monospace;
  letter-spacing: .09em;
  text-transform: uppercase;
}
.micro-process-copy h3 { margin-bottom: 12px; font: 650 20px/1.18 Inter, sans-serif; }
.micro-process-copy p { margin: 0; color: var(--slate); font-size: 13px; line-height: 1.62; }
.profile-value-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 18px; }
.profile-value-grid .micro-process-step { display: flex; flex-direction: column; }
.profile-value-grid .micro-process-step figure { height: 230px; }
.profile-value-grid .micro-process-copy { flex: 1; }
.longitudinal-section {
  background:
    linear-gradient(90deg, rgba(23,28,96,.034) 1px, transparent 1px),
    linear-gradient(rgba(23,28,96,.034) 1px, transparent 1px),
    var(--paper);
  background-size: 58px 58px;
}
.longitudinal-story {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 25px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
}
.longitudinal-story article { min-height: 330px; padding: 34px; border-right: 1px solid var(--line); }
.longitudinal-story article:last-child { border-right: 0; }
.longitudinal-story article > span { margin-bottom: 74px; }
.longitudinal-story h3 { margin-bottom: 14px; font: 650 23px/1.18 Inter, sans-serif; }
.longitudinal-story p { margin: 0; color: var(--slate); font-size: 14px; }
.future-value-callout {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 64px;
  align-items: center;
  margin-top: 26px;
  padding: 48px;
  border-radius: 25px;
  color: var(--white);
  background:
    radial-gradient(circle at 95% 8%, rgba(239,96,104,.24), transparent 38%),
    var(--navy-deep);
  box-shadow: var(--shadow);
}
.future-value-callout span { color: #ffabb1; }
.future-value-callout h3 { margin: 0; color: var(--white); font: 500 clamp(30px, 3.6vw, 45px)/1.12 "Playfair Display", Georgia, serif; }
.future-value-callout p { margin-bottom: 19px; color: rgba(255,255,255,.7); font-size: 15px; }
.future-value-callout strong {
  display: block;
  padding: 18px 20px;
  border-left: 3px solid var(--coral);
  color: var(--white);
  background: rgba(255,255,255,.07);
  font-size: 14px;
  line-height: 1.55;
}
.disease-direction {
  display: grid;
  grid-template-columns: .8fr 1.2fr;
  gap: 54px;
  align-items: center;
  margin-top: 26px;
  padding: 40px 44px;
  border: 1px solid var(--line);
  border-radius: 25px;
  background: var(--cream);
}
.disease-direction-copy > span { margin-bottom: 13px; }
.disease-direction-copy h3 { margin-bottom: 13px; font: 500 32px/1.13 "Playfair Display", Georgia, serif; }
.disease-direction-copy p { margin: 0; color: var(--slate); font-size: 13px; }
.disease-direction-list { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; }
.disease-direction-list span {
  display: flex;
  min-height: 72px;
  align-items: center;
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 15px;
  color: var(--navy);
  background: var(--white);
  font-weight: 700;
}
.detail-related { background: var(--paper); }
.related-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 20px; }
.related-card {
  display: flex;
  min-height: 230px;
  padding: 28px;
  border: 1px solid var(--line);
  border-radius: 21px;
  background: var(--white);
  box-shadow: var(--shadow-soft);
  flex-direction: column;
  transition: transform .2s ease, box-shadow .2s ease;
}
.related-card:hover { transform: translateY(-4px); box-shadow: var(--shadow); }
.related-card span {
  display: block;
  margin-bottom: 55px;
  color: var(--coral-dark);
  font: 600 10px/1.3 "DM Mono", monospace;
  letter-spacing: .1em;
  text-transform: uppercase;
}
.related-card strong { display: block; margin-bottom: 10px; color: var(--navy); font-size: 19px; line-height: 1.2; }
.related-card small { color: var(--slate); font-size: 12px; line-height: 1.55; }

/* CTA and footer */
.cta-band { padding: 96px 0; color: var(--white); background: var(--navy); }
.cta-inner { text-align: center; }
.cta-band .eyebrow { justify-content: center; color: #ff9ca2; }
.cta-band h2 { max-width: 850px; margin: 0 auto 18px; color: var(--white); font-size: clamp(38px, 5vw, 62px); }
.cta-band p { max-width: 720px; margin: 0 auto 30px; color: rgba(255,255,255,.68); }
.cta-actions { display: flex; flex-wrap: wrap; justify-content: center; gap: 12px; }
.baseline-cta { padding: 82px 0; }
.baseline-cta-grid {
  display: grid;
  grid-template-columns: minmax(0, .82fr) minmax(500px, 1.18fr);
  gap: 58px;
  align-items: center;
}
.baseline-cta .eyebrow { justify-content: flex-start; }
.baseline-cta h2 { max-width: 620px; margin: 0 0 20px; font-size: clamp(38px, 4.2vw, 58px); }
.baseline-cta p { max-width: 590px; margin: 0 0 30px; }
.baseline-cta .cta-actions { justify-content: flex-start; }
.baseline-cta-visual {
  position: relative;
  overflow: hidden;
  margin: 0;
  aspect-ratio: 1;
  border: 1px solid rgba(255,255,255,.17);
  border-radius: 28px;
  background: var(--navy-deep);
  box-shadow: 0 30px 70px rgba(3,9,36,.35);
}
.baseline-cta-visual::after {
  position: absolute;
  inset: 0;
  content: "";
  pointer-events: none;
  background: linear-gradient(180deg, transparent 58%, rgba(4,11,38,.76) 100%);
}
.baseline-cta-visual img { width: 100%; height: 100%; object-fit: cover; }
.baseline-cta-visual figcaption {
  position: absolute;
  right: 22px;
  bottom: 18px;
  left: 22px;
  z-index: 1;
  color: rgba(255,255,255,.7);
  font: 500 9px/1.45 "DM Mono", monospace;
  letter-spacing: .045em;
  text-transform: uppercase;
}
footer { padding: 72px 0 28px; color: rgba(255,255,255,.7); background: var(--navy-deep); }
.footer-grid { display: grid; grid-template-columns: 1.25fr .7fr .95fr; gap: 70px; padding-bottom: 52px; }
.footer-logo { width: 220px; margin-bottom: 20px; padding: 8px 10px; border-radius: 10px; background: var(--white); }
.footer-brand p { max-width: 390px; font-size: 13px; }
.footer-col { display: flex; gap: 10px; flex-direction: column; font-size: 13px; }
.footer-col strong { margin-bottom: 6px; color: var(--white); }
.footer-col a:hover { color: var(--white); }
.footer-bottom { display: flex; justify-content: space-between; gap: 32px; padding-top: 24px; border-top: 1px solid rgba(255,255,255,.12); font-size: 11px; }
.footer-disclosure { max-width: 700px; text-align: right; }

@media (max-width: 1060px) {
  .nav-links { gap: 14px; }
  .nav-links a { font-size: 11px; }
  .card-grid.four { grid-template-columns: 1fr 1fr; }
  .micro-process { grid-template-columns: 1fr 1fr; }
  .profile-grid, .partner-grid, .related-grid { grid-template-columns: 1fr 1fr; }
}

@media (max-width: 900px) {
  .hero-grid, .section-intro, .callout { grid-template-columns: 1fr; }
  .hero-grid { gap: 45px; }
  .summary-grid { grid-template-columns: 1fr 1fr; }
  .story-image-grid { grid-template-columns: 1fr 1fr; }
  .story-image-card:first-child { grid-column: 1 / -1; }
  .summary-item { border-bottom: 1px solid var(--line); }
  .summary-item:nth-child(2) { border-right: 0; }
  .summary-item:first-child, .summary-item:nth-child(3) { padding-left: 0; }
  .card-grid, .card-grid.two { grid-template-columns: 1fr; }
  .card-code { margin-bottom: 35px; }
  .video-feature { grid-template-columns: 1fr; }
  .video-frame { min-height: 0; aspect-ratio: 16 / 9; }
  .pathway { grid-template-columns: 1fr; }
  .pathway-step { min-height: auto; border-right: 0; border-bottom: 1px solid var(--line); }
  .pathway-step:last-child { border-bottom: 0; }
  .pathway-step:not(:last-child)::after { top: auto; right: 28px; bottom: -12px; transform: rotate(90deg); }
  .pathway-step span { margin-bottom: 25px; }
  .timeline-notes { grid-template-columns: 1fr 1fr; }
  .partner-flow { grid-template-columns: 1fr 1fr; }
  .partner-step:nth-child(2) { border-right: 0; }
  .partner-step { border-bottom: 1px solid rgba(255,255,255,.14); }
  .partner-step:nth-child(n+3) { border-bottom: 0; }
  .mirna-hero-card { width: min(100%, 680px); margin-inline: auto; }
  .mirna-pattern-layout { grid-template-columns: 1fr; }
  .pattern-proof-card { width: min(100%, 620px); margin-inline: auto; }
  .credibility-grid, .future-value-callout, .disease-direction { grid-template-columns: 1fr; }
  .baseline-cta-grid { grid-template-columns: 1fr; }
  .baseline-cta-copy { max-width: 720px; }
  .combined-foundation-grid, .published-proof-wide { grid-template-columns: 1fr; }
  .combined-video { min-height: 0; aspect-ratio: 16 / 9; }
  .published-proof-identity { min-height: 330px; border-right: 0; border-bottom: 1px solid var(--line); }
  .credibility-card { min-height: 500px; }
  .profile-value-grid { grid-template-columns: 1fr; }
  .longitudinal-story { grid-template-columns: 1fr; }
  .longitudinal-story article { min-height: auto; border-right: 0; border-bottom: 1px solid var(--line); }
  .longitudinal-story article:last-child { border-bottom: 0; }
  .longitudinal-story article > span { margin-bottom: 32px; }
}

@media (max-width: 720px) {
  .wrap { width: min(calc(100% - 32px), var(--wrap)); }
  .section { padding: 78px 0; }
  .nav { height: 76px; }
  .logo { width: 178px; }
  .nav-links { display: none; }
  .nav-links.is-open {
    display: block;
    position: absolute;
    top: 67px;
    right: 16px;
    left: 16px;
    padding: 20px;
    border: 1px solid rgba(255,255,255,.15);
    border-radius: 20px;
    background: var(--navy-deep);
    box-shadow: 0 20px 50px rgba(0,0,0,.25);
  }
  .nav-links.is-open a, .nav-links.is-open a:not(.nav-product) { display: block; padding: 14px 10px; box-shadow: none; }
  .nav-links.is-open .nav-product { margin-top: 6px; text-align: center; }
  .menu-toggle { display: block; }
  .hero-grid { min-height: auto; padding: 62px 0 72px; }
  .hero-copy h1 { font-size: clamp(44px, 14vw, 62px); }
  .hero-actions { flex-direction: column; align-items: stretch; }
  .visual-card { min-height: auto; padding: 24px; }
  .mirna-hero-card { border-radius: 22px; }
  .mirna-hero-card figcaption { padding: 24px 20px; }
  .mirna-hero-card h2 { font-size: 27px; }
  .visual-row { grid-template-columns: 55px 1fr; }
  .summary-grid, .story-image-grid, .card-grid.four, .mode-grid, .profile-grid, .partner-grid, .fit-panel, .related-grid, .footer-grid { grid-template-columns: 1fr; }
  .story-image-card:first-child { grid-column: auto; }
  .story-image-card { min-height: 280px; }
  .summary-item, .summary-item:first-child, .summary-item:nth-child(3) { padding: 22px 0; border-right: 0; }
  .info-card { min-height: auto; padding: 28px 24px; }
  .route-card { min-height: 350px; }
  .callout { padding: 31px 25px; gap: 30px; }
  .control-layer { grid-template-columns: 80px 1fr; padding: 18px; }
  .video-copy { padding: 29px 24px; }
  .trajectory-shell { padding: 22px 15px; }
  .trajectory-head { display: block; }
  .trajectory-tag { display: block; margin-top: 12px; }
  .trajectory-canvas { height: 300px; }
  .timeline-notes { grid-template-columns: 1fr; }
  .quote-feature { grid-template-columns: 1fr; padding: 30px 24px; text-align: center; }
  .quote-photo { margin-inline: auto; }
  .profile-card, .partner-card { min-height: auto; }
  .evidence-image-card { grid-template-columns: 1fr; }
  .evidence-image-card img { min-height: 0; }
  .evidence-image-card figcaption { padding: 26px 23px; }
  .pattern-explanation > article { grid-template-columns: 1fr; row-gap: 10px; }
  .pattern-explanation > article > span { grid-row: auto; }
  .pattern-proof-card { aspect-ratio: auto; }
  .pattern-proof-image { min-height: 270px; }
  .proof-heading { margin-bottom: 38px; }
  .comparison-banner-inner { min-height: 58px; align-items: flex-start; padding-block: 12px; flex-direction: column; gap: 4px; }
  .combined-foundation-copy { padding: 31px 24px; }
  .combined-foundation-copy h2 { font-size: 43px; }
  .combined-nobel-mark { grid-template-columns: 1fr; gap: 10px; }
  .published-proof-identity { min-height: 300px; padding: 30px 24px; }
  .published-proof-copy { padding: 32px 24px; }
  .published-proof-copy h2 { font-size: 37px; }
  .credibility-card { min-height: auto; }
  .credibility-body { padding: 30px 24px; }
  .credibility-mark { margin-bottom: 34px; font-size: 66px; }
  .published-logo-wrap { align-items: flex-start; flex-direction: column; }
  .published-logo-wrap img { width: 220px; max-width: 80%; }
  .micro-process { grid-template-columns: 1fr; }
  .micro-process-step figure { height: 210px; }
  .profile-value-grid .micro-process-step figure { height: 230px; }
  .longitudinal-story article { padding: 29px 24px; }
  .future-value-callout { gap: 28px; padding: 32px 24px; }
  .disease-direction { gap: 27px; padding: 31px 24px; }
  .baseline-cta { padding: 72px 0; }
  .baseline-cta-visual { border-radius: 22px; }
  .baseline-cta-visual figcaption { right: 16px; bottom: 14px; left: 16px; }
  .disease-direction-list { grid-template-columns: 1fr; }
  .detail-photo-break { padding-top: 28px; }
  .detail-photo-feature { min-height: 300px; border-radius: 22px; }
  .detail-photo-feature::after { background: linear-gradient(0deg, rgba(8,21,51,.92) 0%, rgba(8,21,51,.34) 62%, rgba(8,21,51,.04) 100%); }
  .detail-photo-feature figcaption { padding: 28px 24px; }
  .related-card { min-height: auto; }
  .profile-tag, .partner-tag { margin-bottom: 35px; }
  .fit-side:first-child { border-right: 0; border-bottom: 1px solid var(--line); }
  .partner-flow { grid-template-columns: 1fr; }
  .partner-step { min-height: auto; border-right: 0; border-bottom: 1px solid rgba(255,255,255,.14) !important; }
  .partner-step:last-child { border-bottom: 0 !important; }
  .partner-step span { margin-bottom: 35px; }
  .footer-grid { gap: 30px; }
  .footer-bottom { flex-direction: column; }
  .footer-disclosure { text-align: left; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { transition-duration: .01ms !important; }
  .reveal { opacity: 1; transform: none; }
}